MM 500 MIXER MILL NANO INTRODUCTION
HIGH SPEED BALL MILLING WITH EASY OPERATION FOR BEST RESULTS
- Max. speed 35 Hz
- Horizontal oscillation causes strong impact effects for effective sample processing
- Up to 10 mm feed size and 0.1 µm final fineness
- 2 grinding stations for jars of min. 2 ml and max. 125 ml, adapter for 18 x 2 ml single use vials
- Steel jars can be precooled manually in liquid nitrogen
- GrindControl to measure temperature and pressure inside the jar.
- Aeriation lids to control the atmosphere inside the jar
- Bench top model, touch screen, easy jar clamping, jars can stay clamped for subsampling, storable SOPs and cycle programs, 4 different jar materials for dry and wet grinding
ADVANCES THROUGH DESIGN
- Thanks to the flat lid, the nominal volume can be used optimally, for example to accommodate sufficient fibrous samples or to achieve the best mixture of sample, small grinding balls and liquid for wet grinding.
- Screw-Lock grinding jars (50 / 80 / 125 ml) for dry, wet or cryogenic grinding
- Very easy, comfortable clamping and handling of the grinding jars, which are pressure-tight up to 5 bar
- Jars can stay clamped while taking a sub-sample or visual checks of fineness
- Ergonomic design with touch display for easy parameter setting
- 12 SOPs & 4 program cycles with up to 99 repeats to facilitate routine applications
FLEXIBILITY
- Equally suited for rapid pulverization <2 min and long-term grinding up to 99 hours
- Use one large grinding ball in the High Impact mode or several smaller balls in the High Friction mode
- Use the MM 500 nano for routine sample preparation applications, for nano-grinding or for research applications such as mechanochemistry and mechanical alloying
Mechanochemistry in the Pharmaceutical Industry
SUSTAINABLE PRODUCTION OF ACTIVE PHARMACEUTICAL INGREDIENTS WITH MAXIMUM EFFICIENCY
To control the temperature of a grinding process, the mill needs to be connected to an external tempering device. Basically, there are two options:
Discover how mechanochemical methods can contribute to the production of active pharmaceutical ingredients—with higher atomic efficiency, fewer byproducts, and a significantly reduced environmental footprint.
Mechanochemistry opens up new avenues for more sustainable chemical synthesis: By utilizing mechanical energy, reactions can be carried out in the solid state—often with no solvents at all or only minimal use of solvents. This reduces waste, lowers energy consumption, and simultaneously improves process efficiency.
Vibrating mills such as the MM 500 nano enable precise control of grinding parameters and are particularly suitable for fast, efficient syntheses on a laboratory scale. For more demanding applications requiring higher energies, the planetary ball mill PM 100 offers optimal conditions for carrying out even complex reactions in a targeted manner.
Take a look!
GRIND SIZES IN THE NANOMETER RANGE
- New jar design allows for optimized usage of jar volume also for wet grinding
- Final fineness < 100 nm possible thanks to maximized energy input at 35 Hz
- Less warming effects, thus grinding can usually be done without grinding breaks for cooling down
Result: You get your nano sample within the shortest time.
Nano grinding of 25 g titanium dioxide in a 125 ml grinding jar zirconium oxide with 275 g balls 0.1 mm, 30 ml 1% NaPO4 solution. A particle size of 90 nm was achievied after 120 minutes of grinding.
ACCESSORIES FOR MAXIMUM FLEXIBILITY
GRINDING JARS IN 3 DIFFERENT MATERIALS
Available grinding jar sizes are 50 ml, 80 ml and 125 ml, materials include stainless steel, tungsten carbide and zirconium oxide, ensuring contamination-free sample preparation. Heavy-metal-free grinding is possible, also at -100 °C
AERATION LID VIDEO
RETSCH offers a special aeration lid for the grinding jars designed for applications where a special atmosphere is to be maintained in the ball mill jar.
GRINDCONTROL
he GrindControl measures temperature and pressure inside the jar. The system includes a sensor and transmission unit as well as an analysis software.
MULTI-CAVITY JARS & ADAPTERS
Simultaneous processing of several small samples is possible with the multi-cavity jars and an adapter for reaction vials. This is a typical requirement, for example, for pharmaceutical, chemical and biochemical applications. The small cavity jars provide new opportunities for mechanochemical research activities involving small amounts of chemicals.
The cavities in the jars have an oval shape which ensures effective mixing. The pouring aids allow for safe sample handling. The multi-cavity jars are made of stainless steel, thus providing effective heat transfer to or from the sample.
The adapter accommodates up to 18 disposable reaction vials of 1.5 or 2.0 ml (e.g. Eppendorf vials) or nine 2.0 ml steel tubes. With its two grinding stations, the MM 500 control mixer mill can now process up to 36 samples in one working run. 2.0 ml steel tubes should be used if samples need to be frozen or heated, as polymeric reaction vessels cannot withstand mechanical load at extreme temperatures. The adapter is made of aluminum so that heat is efficiently transferred to and from the reaction tubes.
Multi-cavity jars of 4 x 10 ml and 2 x 25 ml, made of stainless steel, incl. PTFE pouring aids.
Adapter for 18 x 2 ml safe-lock reaction vials or 9 x 2 ml steel tubes, made of aluminum
TYPICAL SAMPLE MATERIALS
RETSCH mixer mills are true allrounders. They homogenize, for example: alloys, animal feed, bones, ceramics, chemical products, coal, coke, drugs, electronic scrap, glass, grains, hair, minerals, oil seeds, ores, paper, plant materials, plastics, sewage sludge, soils, straw, tablets, textiles, tissue, tobacco, waste samples, wood, wool, etc.
NANO GRINDING OF ALUMINUM OXIDE
Narrow particle size distribution of aluminium oxide after grinding (Nano grinding of 30 g aluminum oxide in a 125 ml grinding jar zirconium oxide with 275 g balls 0.1 mm, 33 ml 0.5% NaPO4 solution)
FUNCTIONAL PRINCIPAL
The grinding jars of the mixer mill MM 500 nano perform radial oscillations in a horizontal position. The inertia of the grinding balls causes them to impact with high energy on the sample material at the rounded ends of the grinding jars and pulverize it. Also, the movement of the grinding jars combined with the movement of the balls result in the intensive mixing of the sample. The degree of mixing can be increased even further by using several smaller balls.
TECHNICAL DATA
| Applications | mechanochemistry, mechanical alloying, size reduction, mixing, homogenization, cryogenic grinding |
| Field of application | agriculture, biology, chemistry / plastics, construction materials, engineering / electronics, environment / recycling, food, geology / metallurgy, glass / ceramics, medicine / pharmaceuticals |
| Feed material | hard, medium-hard, soft, brittle, elastic, fibrous |
| Size reduction principle | impact, friction |
| Material feed size* | <= 10 mm |
| Final fineness* | ~ 0.1 µm |
| Batch size / feed quantity* | max. 2 x 45 ml |
| No. of grinding stations | 2 |
| Vibrational frequency | 3 – 35 Hz (180 – 2100 min-1) |
| Typical mean grinding time | 30 s – 2 min |
| Dry grinding | yes |
| Wet grinding | yes |
| Cryogenic grinding | yes |
| Cell disruption with reaction vials | no |
| Type of grinding jars | screw-lock jar with integrated safety closure devices, multi cavity jar, adapter for safe-lock reaction vials |
| Material of grinding tools | hardened steel, stainless steel, tungsten carbide, zirconium oxide |
| Grinding jar sizes | 10 ml / 25 ml / 50 ml / 80 ml / 125 ml |
| Setting of grinding time | digital, 10 s – 8 h |
| Total grinding time | 99 h |
| Storable SOPs | 12 |
| Number of storable cycle programs | 4 (with 99 repeats) |
| Electrical supply data | 100-120 V, 50/60 Hz; 200-230 V, 50/60Hz |
| Power connection | 1-phase |
| Protection code | IP 30 |
| Power consumption | 750 W |
| W x H x D closed | 690 x 375 x 585 mm |
| Net weight | ~ 60 kg |
| Standards | CE |
*depending on feed material and instrument configuration/settings
